Ultrasonic DNA Cleaver

The principle of ultrasonic DNA shearing instruments is based on the mechanical vibrations and cavitation effects generated by ultrasound. High-frequency electrical signals produced by the ultrasonic generator are converted into mechanical vibrations via a transducer, which are then applied to the liquid containing the DNA sample.

Under ultrasonic influence, microscopic bubbles form within the liquid medium. These bubbles rapidly expand and implode, generating intense shock waves and microjets capable of penetrating cell membranes and nucleic acid molecules. This process precisely breaks DNA molecular chains, making it applicable for bacterial cell disruption, protein extraction, DNA fragmentation for next-generation sequencing samples, immunoprecipitation experiments, fungal spore disruption, emulsification, homogenization, accelerated dissolution, and catalytic reactions. It plays a particularly crucial role in DNA sample processing for molecular biology research.

The device features a 7-inch touchscreen interface with customizable settings for ultrasonic duration, interval time, power output, and alarm temperature thresholds. It includes real-time sample temperature monitoring, operates at a nominal frequency of 23 kHz with adaptive tuning, and incorporates automatic fault alerts.

Applications span the following fields:
1. Genomics: NGS library preparation (WGS, WES), metagenomics research.
2. Next-Generation Sequencing (NGS): DNA fragmentation during library preparation.
3. Epigenetics research: Sample processing for ChIP-seq, ATAC-seq, and similar experiments.
4. Molecular diagnostics: Fragmentation of DNA extracted from FFPE samples.
5. Synthetic biology: Preparation of DNA fragments prior to genome assembly.
6. Forensic testing: Standardized processing of trace DNA samples.

• High throughput and flexible configuration accommodate test samples of varying capacities, meeting diverse experimental requirements.

• Battery-powered rotary motor simplifies installation and enables rapid deployment of the equipment.

• External low-temperature water bath interface allows connection to a chiller for precise sample temperature control, preventing sample denaturation—ideal for temperature-sensitive sample processing.

• Automatic fault alarm (or protection) function continuously monitors device status, promptly detecting and alerting to anomalies to ensure safe and stable operation.

• 7-inch medical-grade LCD touchscreen with high resolution, intuitive interface, and smooth operation.

• Flexible ultrasonic parameter settings ensure excellent experimental reproducibility and high result reliability.

• Each sample is processed in a separate, fully sealed tube, effectively preventing cross-contamination and guaranteeing accurate experimental results.

• Nominal 23KHz ultrasonic function with adaptive frequency capability accommodates diverse sample processing needs and enhances disruption efficiency.